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In LOX-/- mice, it was reported that the mice died perinatally due to aortic aneurysms, cardiovascular dysfunction and diaphragmatic ruptures (20)

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My work and that of others suggest that many synthetic dyes widely used in foods and medicines can trigger potentially harmful immune system reactions in the body

Liu HT and Kuo HC: Intravesical botulinum toxin a injections plus hydrodistension can reduce nerve growth factor production and control bladder pain in interstitial cystitis

Option (Evidence Strength: Grade C) One randomized trial with an oral PPS group for comparison reported that CyA (3 mg/ kg/day divided into two doses) resulted in 75% of patients experiencing clinically significant improvement compared to 19% of a PPS comparison group after six months of treatment